Cargando…

TCRζ(dim)lymphocytes define populations of circulating effector cells that migrate to inflamed tissues

The T-cell receptor ζ (TCRζ) chain is a master sensor and regulator of lymphocyte responses. Loss of TCRζ expression has been documented in infectious, inflammatory, and malignant diseases, suggesting that it may serve to limit T-cell reactivity and effector responses at sites of tissue damage. Thes...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Zhuoli, Gorman, Claire L., Vermi, Anna-Chiara, Monaco, Claudia, Foey, Andrew, Owen, Sally, Amjadi, Parisa, Vallance, Alena, McClinton, Catherine, Marelli-Berg, Federica, Isomäki, Pia, Russell, Andrew, Dazzi, Francesco, Vyse, Timothy J., Brennan, Fionula M., Cope, Andrew P.
Formato:	Texto
Lenguaje:	English
Publicado:	American Society of Hematology 2007
Materias:	Immunobiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1939810/ https://www.ncbi.nlm.nih.gov/pubmed/17255353 http://dx.doi.org/10.1182/blood-2006-12-064170

Ejemplares similares

Sustained downregulation of the TCRζ chain defines a transition from antigen mode to inflammation mode during terminal T-cell differentiation
por: Zhang, Z, et al.
Publicado: (2005)

Activation of the Hedgehog signaling pathway in T-lineage cells inhibits TCR repertoire selection in the thymus and peripheral T-cell activation
por: Rowbotham, Nicola J., et al.
Publicado: (2007)

The Transmembrane Adaptor Protein Trim Regulates T Cell Receptor (Tcr) Expression and Tcr-Mediated Signaling via an Association with the Tcr ζ Chain
por: Kirchgessner, Henning, et al.
Publicado: (2001)

NK cells CD56(bright) and CD56(dim) subset cytokine loss and exhaustion is associated with impaired survival in myeloma
por: Seymour, Frances, et al.
Publicado: (2022)

Clonal regulatory T cells specific for a red blood cell autoantigen in human autoimmune hemolytic anemia
por: Ward, Frank J., et al.
Publicado: (2008)

Critical but divergent roles for CD62L and CD44 in directing blood monocyte trafficking in vivo during inflammation
por: Xu, Heping, et al.
Publicado: (2008)

Resolution-phase macrophages possess a unique inflammatory phenotype that is controlled by cAMP
por: Bystrom, Jonas, et al.
Publicado: (2008)

Wiskott-Aldrich syndrome protein deficiency in B cells results in impaired peripheral homeostasis
por: Meyer-Bahlburg, Almut, et al.
Publicado: (2008)

Chemokine up-regulation in SARS-coronavirus–infected, monocyte-derived human dendritic cells
por: Law, Helen K.W., et al.
Publicado: (2005)

High frequency of CD4(+)FoxP3(+) cells in HTLV-1 infection: inverse correlation with HTLV-1–specific CTL response
por: Toulza, Frederic, et al.
Publicado: (2008)

Novel biphasic role for lymphocytes revealed during resolving inflammation
por: Rajakariar, Ravindra, et al.
Publicado: (2008)

Evidence of dysregulation of dendritic cells in primary HIV infection
por: Sabado, Rachel Lubong, et al.
Publicado: (2010)

SATB1 dictates expression of multiple genes including IL-5 involved in human T helper cell differentiation
por: Ahlfors, Helena, et al.
Publicado: (2010)

The host genomic environment of the provirus determines the abundance of HTLV-1–infected T-cell clones
por: Gillet, Nicolas A., et al.
Publicado: (2011)

Selective homing of CAR-CIK cells to the bone marrow niche enhances control of the acute myeloid leukemia burden
por: Biondi, Marta, et al.
Publicado: (2023)

Unmasking the suppressed immunopeptidome of EZH2-mutated diffuse large B-cell lymphomas through combination drug treatment
por: Bourne, Christopher M., et al.
Publicado: (2022)

Cytokine regulation in RA synovial tissue: role of T cell/macrophage contact-dependent interactions
por: Brennan, Fionula Mary, et al.
Publicado: (2002)

Cytokine-induced natural killer cell training is dependent on cellular metabolism and is defective in obesity
por: Kedia-Mehta, Nidhi, et al.
Publicado: (2021)

Immune profiling after allogeneic hematopoietic cell transplantation in pediatric acute myeloid leukemia
por: Shahid, Sanam, et al.
Publicado: (2023)

Engineering amino acid uptake or catabolism promotes CAR T-cell adaption to the tumor environment
por: Panetti, Silvia, et al.
Publicado: (2022)

Sodium stibogluconate and CD47-SIRPα blockade overcome resistance of anti-CD20–opsonized B cells to neutrophil killing
por: van Rees, Dieke J., et al.
Publicado: (2022)

Using stroma-anchoring cytokines to augment ADCC: a phase 1 trial of F16IL2 and BI 836858 for posttransplant AML relapse
por: Berdel, Andrew F., et al.
Publicado: (2022)

A subset of memory effector T cells in peripheral blood defined by differential expression of the TCR-ζ chain
por: Zhang, Z, et al.
Publicado: (2003)

Resting CD4(+ )effector memory T cells are precursors of bystander-activated effectors: a surrogate model of rheumatoid arthritis synovial T-cell function
por: Brennan, Fionula M, et al.
Publicado: (2008)

Impaired natural killer cell counts and cytolytic activity in patients with severe COVID-19
por: Osman, Mohammed, et al.
Publicado: (2020)

SARS-CoV-2–specific T cells are rapidly expanded for therapeutic use and target conserved regions of the membrane protein
por: Keller, Michael D., et al.
Publicado: (2020)

Catch those antibodies before they fall
por: Shaz, Beth H., et al.
Publicado: (2020)

Expanding the toolbox to combat a pandemic
por: Prockop, Susan E.
Publicado: (2020)

Venetoclax enhances T cell–mediated antileukemic activity by increasing ROS production
por: Lee, Jong Bok, et al.
Publicado: (2021)

Defining the AHR-regulated transcriptome in NK cells reveals gene expression programs relevant to development and function
por: Trikha, Prashant, et al.
Publicado: (2021)

Functional characterization of 105 factor H variants associated with aHUS: lessons for variant classification
por: Martín Merinero, Hector, et al.
Publicado: (2021)

Thrombocytopenia and splenic platelet-directed immune responses after IV ChAdOx1 nCov-19 administration
por: Nicolai, Leo, et al.
Publicado: (2022)

FlowCT for the analysis of large immunophenotypic data sets and biomarker discovery in cancer immunology
por: Botta, Cirino, et al.
Publicado: (2022)

Tisagenlecleucel outcomes in relapsed/refractory extramedullary ALL: a Pediatric Real World CAR Consortium Report
por: Fabrizio, Vanessa A., et al.
Publicado: (2022)

Characterization of extramedullary disease in B-ALL and response to CAR T-cell therapy
por: Holland, Elizabeth M., et al.
Publicado: (2022)

GM-CSF secreting leukemia cell vaccination for MDS/AML after allogeneic HSCT: a randomized, double-blinded, phase 2 trial
por: Ho, Vincent T., et al.
Publicado: (2022)

Infectious complications in patients with relapsed refractory multiple myeloma after BCMA CAR T-cell therapy
por: Kambhampati, Swetha, et al.
Publicado: (2022)

Fludarabine exposure predicts outcome after CD19 CAR T-cell therapy in children and young adults with acute leukemia
por: Dekker, Linde, et al.
Publicado: (2022)

Severe cytokine release syndrome is associated with hematologic toxicity following CD19 CAR T-cell therapy
por: Juluri, Krishna R., et al.
Publicado: (2022)

Antigen-specific immunotherapy with apitopes suppresses generation of FVIII inhibitor antibodies in HLA-transgenic mice
por: Pletinckx, Katrien, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ndicu6mu11msmt13js7r9fiq4m