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Arf6 recruits the Rac GEF Kalirin to the plasma membrane facilitating Rac activation

BACKGROUND: Many studies implicate Arf6 activity in Rac-mediated membrane ruffling and cytoskeletal reorganization. Although Arf6 facilitates the trafficking of Rac1 to the plasma membrane and in many cases Arf6 activation leads to the activation of Rac1, the details of how Arf6 influences Rac funct...

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Detalles Bibliográficos
Autores principales: Koo, Tae Hyeon, Eipper, Betty A, Donaldson, Julie G
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1939998/
https://www.ncbi.nlm.nih.gov/pubmed/17640372
http://dx.doi.org/10.1186/1471-2121-8-29