Somatic CTG•CAG repeat instability in a mouse model for myotonic dystrophy type 1 is associated with changes in cell nuclearity and DNA ploidy

BACKGROUND: Trinucleotide instability is a hallmark of degenerative neurological diseases like Huntington's disease, some forms of spinocerebellar ataxia and myotonic dystrophy type 1 (DM1). To investigate the effect of cell type and cell state on the behavior of the DM1 CTG•CAG repeat, we stud...

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Detalles Bibliográficos
Autores principales: van den Broek, Walther JAA, Wansink, Derick G, Wieringa, Bé
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1940261/
https://www.ncbi.nlm.nih.gov/pubmed/17645799
http://dx.doi.org/10.1186/1471-2199-8-61

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1940261/
https://www.ncbi.nlm.nih.gov/pubmed/17645799
http://dx.doi.org/10.1186/1471-2199-8-61

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