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Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1, 6-heptadiene-3,5-dione) Blocks the Chemotaxis of Neutrophils by Inhibiting Signal Transduction through IL-8 Receptors
We investigated the impact of curcumin on neutrophils. Chemotactic activity via human recombinant IL-8 (hrIL-8) was significantly inhibited by curcumin. Curcumin reduced calcium ion flow induced by internalization of the IL-8 receptor. We analyzed flow cytometry to evaluate the status of the IL-8 re...
Autores principales: | Takahashi, Masafumi, Ishiko, Takatoshi, Kamohara, Hidenobu, Hidaka, Hideaki, Ikeda, Osamu, Ogawa, Michio, Baba, Hideo |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1940327/ https://www.ncbi.nlm.nih.gov/pubmed/17710245 http://dx.doi.org/10.1155/2007/10767 |
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