Coronavirus Non-Structural Protein 1 Is a Major Pathogenicity Factor: Implications for the Rational Design of Coronavirus Vaccines

Attenuated viral vaccines can be generated by targeting essential pathogenicity factors. We report here the rational design of an attenuated recombinant coronavirus vaccine based on a deletion in the coding sequence of the non-structural protein 1 (nsp1). In cell culture, nsp1 of mouse hepatitis vir...

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Detalles Bibliográficos
Autores principales: Züst, Roland, Cervantes-Barragán, Luisa, Kuri, Thomas, Blakqori, Gjon, Weber, Friedemann, Ludewig, Burkhard, Thiel, Volker
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1941747/
https://www.ncbi.nlm.nih.gov/pubmed/17696607
http://dx.doi.org/10.1371/journal.ppat.0030109

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1941747/
https://www.ncbi.nlm.nih.gov/pubmed/17696607
http://dx.doi.org/10.1371/journal.ppat.0030109

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