Cargando…

Coronavirus Non-Structural Protein 1 Is a Major Pathogenicity Factor: Implications for the Rational Design of Coronavirus Vaccines

Attenuated viral vaccines can be generated by targeting essential pathogenicity factors. We report here the rational design of an attenuated recombinant coronavirus vaccine based on a deletion in the coding sequence of the non-structural protein 1 (nsp1). In cell culture, nsp1 of mouse hepatitis vir...

Descripción completa

Detalles Bibliográficos
Autores principales:	Züst, Roland, Cervantes-Barragán, Luisa, Kuri, Thomas, Blakqori, Gjon, Weber, Friedemann, Ludewig, Burkhard, Thiel, Volker
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2007
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1941747/ https://www.ncbi.nlm.nih.gov/pubmed/17696607 http://dx.doi.org/10.1371/journal.ppat.0030109

Ejemplares similares

Control of coronavirus infection through plasmacytoid dendritic-cell–derived type I interferon
por: Cervantes-Barragan, Luisa, et al.
Publicado: (2007)

Dendritic Cell-Specific Antigen Delivery by Coronavirus Vaccine Vectors Induces Long-Lasting Protective Antiviral and Antitumor Immunity
por: Cervantes-Barragan, Luisa, et al.
Publicado: (2010)

Dendritic Cell-Specific Delivery of Flt3L by Coronavirus Vectors Secures Induction of Therapeutic Antitumor Immunity
por: Perez-Shibayama, Christian, et al.
Publicado: (2013)

A Systems Immunology Approach to Plasmacytoid Dendritic Cell Function in Cytopathic Virus Infections
por: Bocharov, Gennady, et al.
Publicado: (2010)

Efficient Transduction of Dendritic Cells Using Coronavirus-Based Vectors
por: Eriksson, Klara K., et al.
Publicado: (2006)

Reverse Genetics of SARS-Related Coronavirus Using Vaccinia Virus-Based Recombination
por: van den Worm, Sjoerd H. E., et al.
Publicado: (2012)

Interferon and cytokine responses to SARS-coronavirus infection
por: Thiel, Volker, et al.
Publicado: (2008)

Nucleocapsid Protein Expression Facilitates Coronavirus Replication
por: Schelle, Barbara, et al.
Publicado: (2006)

Towards a Coronavirus-Based HIV Multigene Vaccine
por: Eriksson, Klara K., et al.
Publicado: (2006)

The small genome segment of Bunyamwera orthobunyavirus harbours a single transcription-termination signal
por: Blakqori, Gjon, et al.
Publicado: (2012)

The SARS-Coronavirus-Host Interactome: Identification of Cyclophilins as Target for Pan-Coronavirus Inhibitors
por: Pfefferle, Susanne, et al.
Publicado: (2011)

Early endonuclease-mediated evasion of RNA sensing ensures efficient coronavirus replication
por: Kindler, Eveline, et al.
Publicado: (2017)

Ribose 2′-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5
por: Züst, Roland, et al.
Publicado: (2011)

Insights into coronavirus immunity taught by the murine coronavirus
por: Grabherr, Sarah, et al.
Publicado: (2021)

Generation of Coronavirus-based multigene RNA vectors
por: Makia, D., et al.
Publicado: (2006)

Numbers Game and Immune Geography as Determinants of Coronavirus Pathogenicity
por: Bocharov, Gennady, et al.
Publicado: (2020)

The intracellular sites of early replication and budding of SARS-coronavirus
por: Stertz, Silke, et al.
Publicado: (2007)

236 SARS-coronavirus inhibits interferon induction both at pre- and post-transcriptional levels
por: Kuri, Thomas, et al.
Publicado: (2008)

Coronavirus biology and replication: implications for SARS-CoV-2
por: V’kovski, Philip, et al.
Publicado: (2020)

Identification and Evaluation of Coronavirus Replicase Inhibitors Using a Replicon Cell Line
por: Scandella, Elke, et al.
Publicado: (2006)

Competitive Fitness in Coronaviruses Is Not Correlated with Size or Number of Double-Membrane Vesicles under Reduced-Temperature Growth Conditions
por: Al-Mulla, Hawaa M. N., et al.
Publicado: (2014)

N7-Methylation of the Coronavirus RNA Cap Is Required for Maximal Virulence by Preventing Innate Immune Recognition
por: Pan, Ruangang, et al.
Publicado: (2022)

Establishment of a reverse genetics system for Schmallenberg virus, a newly emerged orthobunyavirus in Europe
por: Elliott, Richard M., et al.
Publicado: (2013)

Rational Use of Tocilizumab in the Treatment of Novel Coronavirus Pneumonia
por: Zhang, Shengyu, et al.
Publicado: (2020)

In vitro virucidal activity of Echinaforce®, an Echinacea purpurea preparation, against coronaviruses, including common cold coronavirus 229E and SARS-CoV-2
por: Signer, Johanna, et al.
Publicado: (2020)

To sense or not to sense viral RNA — essentials of coronavirus innate immune evasion
por: Kindler, Eveline, et al.
Publicado: (2014)

Molecular targets for the rational design of drugs to inhibit SARS coronavirus
por: Brockway, Sarah M., et al.
Publicado: (2004)

Interaction of SARS and MERS Coronaviruses with the Antiviral Interferon Response
por: Kindler, E., et al.
Publicado: (2016)

Author Correction: In vitro virucidal activity of Echinaforce(®), an Echinacea purpurea preparation, against coronaviruses, including common cold coronavirus 229E and SARS-CoV-2
por: Signer, Johanna, et al.
Publicado: (2020)

Cellular Entry of the SARS Coronavirus: Implications for Transmission, Pathogenicity and Antiviral Strategies
por: Glowacka, Ilona, et al.
Publicado: (2009)

Human pathogen coronaviruses – An overview
por: McFee, R.B.
Publicado: (2020)

Origin and evolution of pathogenic coronaviruses
por: Cui, Jie, et al.
Publicado: (2018)

Highly pathogenic coronaviruses and the kidney
por: Wang, Fang, et al.
Publicado: (2022)

Rational hand hygiene during the coronavirus 2019 (COVID-19) pandemic
por: Cavanagh, Gregory, et al.
Publicado: (2020)

Rationally Designed Chimeric Antibodies for COVID-19 and Future Coronavirus Variants
por: Hsueh, Ching-chung, et al.
Publicado: (2021)

Inhibition of cytokine gene expression and induction of chemokine genes in non-lymphatic cells infected with SARS coronavirus
por: Spiegel, Martin, et al.
Publicado: (2006)

New insights on the role of paired membrane structures in coronavirus replication
por: V’kovski, Philip, et al.
Publicado: (2015)

The Coronavirus Recession and Its Implications
por: Mundle, Sudipto
Publicado: (2020)

Understanding bat SARS-like coronaviruses for the preparation of future coronavirus outbreaks — Implications for coronavirus vaccine development
por: Ng, Oi-Wing, et al.
Publicado: (2016)

Introduction of neutralizing immunogenicity index to the rational design of MERS coronavirus subunit vaccines
por: Du, Lanying, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_tqa515k75obh7t68spp6r1o9k9