Computer-Aided Lead Optimization: Improved Small-Molecule Inhibitor of the Zinc Endopeptidase of Botulinum Neurotoxin Serotype A

Optimization of a serotype-selective, small-molecule inhibitor of botulinum neurotoxin serotype A (BoNTA) endopeptidase is a formidable challenge because the enzyme-substrate interface is unusually large and the endopeptidase itself is a large, zinc-binding protein with a complex fold that is diffic...

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Detalles Bibliográficos
Autores principales: Tang, Jing, Park, Jewn Giew, Millard, Charles B., Schmidt, James J., Pang, Yuan-Ping
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1942119/
https://www.ncbi.nlm.nih.gov/pubmed/17712409
http://dx.doi.org/10.1371/journal.pone.0000761

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1942119/
https://www.ncbi.nlm.nih.gov/pubmed/17712409
http://dx.doi.org/10.1371/journal.pone.0000761

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