Structure of three tandem filamin domains reveals auto-inhibition of ligand binding

Human filamins are large actin-crosslinking proteins composed of an N-terminal actin-binding domain followed by 24 Ig-like domains (IgFLNs), which interact with numerous transmembrane receptors and cytosolic signaling proteins. Here we report the 2.5 Å resolution structure of a three-domain fragment...

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Detalles Bibliográficos
Autores principales: Lad, Yatish, Kiema, Tiila, Jiang, Pengju, Pentikäinen, Olli T, Coles, Charlotte H, Campbell, Iain D, Calderwood, David A, Ylänne, Jari
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2007
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1948075/
https://www.ncbi.nlm.nih.gov/pubmed/17690686
http://dx.doi.org/10.1038/sj.emboj.7601827

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1948075/
https://www.ncbi.nlm.nih.gov/pubmed/17690686
http://dx.doi.org/10.1038/sj.emboj.7601827

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