Interphase Nucleo-Cytoplasmic Shuttling and Localization of SIRT2 during Mitosis

The human NAD+-dependent protein deacetylase SIRT2 resides predominantly in the cytoplasm where it functions as a tubulin deacetylase. Here we report that SIRT2 maintains a largely cytoplasmic localization during interphase by active nuclear export in a Crm1-dependent manner. We identified a functio...

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Detalles Bibliográficos
Autores principales: North, Brian J., Verdin, Eric
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1949146/
https://www.ncbi.nlm.nih.gov/pubmed/17726514
http://dx.doi.org/10.1371/journal.pone.0000784

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1949146/
https://www.ncbi.nlm.nih.gov/pubmed/17726514
http://dx.doi.org/10.1371/journal.pone.0000784

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