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Interphase Nucleo-Cytoplasmic Shuttling and Localization of SIRT2 during Mitosis
The human NAD+-dependent protein deacetylase SIRT2 resides predominantly in the cytoplasm where it functions as a tubulin deacetylase. Here we report that SIRT2 maintains a largely cytoplasmic localization during interphase by active nuclear export in a Crm1-dependent manner. We identified a functio...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2007
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1949146/ https://www.ncbi.nlm.nih.gov/pubmed/17726514 http://dx.doi.org/10.1371/journal.pone.0000784 |