Unbiased Gene Expression Analysis Implicates the huntingtin Polyglutamine Tract in Extra-mitochondrial Energy Metabolism

The Huntington's disease (HD) CAG repeat, encoding a polymorphic glutamine tract in huntingtin, is inversely correlated with cellular energy level, with alleles over ∼37 repeats leading to the loss of striatal neurons. This early HD neuronal specificity can be modeled by respiratory chain inhib...

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Detalles Bibliográficos
Autores principales: Lee, Jong-Min, Ivanova, Elena V, Seong, Ihn Sik, Cashorali, Tanya, Kohane, Isaac, Gusella, James F, MacDonald, Marcy E
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1950164/
https://www.ncbi.nlm.nih.gov/pubmed/17708681
http://dx.doi.org/10.1371/journal.pgen.0030135

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1950164/
https://www.ncbi.nlm.nih.gov/pubmed/17708681
http://dx.doi.org/10.1371/journal.pgen.0030135

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