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Unbiased Gene Expression Analysis Implicates the huntingtin Polyglutamine Tract in Extra-mitochondrial Energy Metabolism

The Huntington's disease (HD) CAG repeat, encoding a polymorphic glutamine tract in huntingtin, is inversely correlated with cellular energy level, with alleles over ∼37 repeats leading to the loss of striatal neurons. This early HD neuronal specificity can be modeled by respiratory chain inhib...

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Detalles Bibliográficos
Autores principales:	Lee, Jong-Min, Ivanova, Elena V, Seong, Ihn Sik, Cashorali, Tanya, Kohane, Isaac, Gusella, James F, MacDonald, Marcy E
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2007
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1950164/ https://www.ncbi.nlm.nih.gov/pubmed/17708681 http://dx.doi.org/10.1371/journal.pgen.0030135

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