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H Bonding at the Helix-Bundle Crossing Controls Gating in Kir Potassium Channels

Specific stimuli such as intracellular H(+) and phosphoinositides (e.g., PIP(2)) gate inwardly rectifying potassium (Kir) channels by controlling the reversible transition between the closed and open states. This gating mechanism underlies many aspects of Kir channel physiology and pathophysiology;...

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Detalles Bibliográficos
Autores principales: Rapedius, Markus, Fowler, Philip W., Shang, Lijun, Sansom, Mark S.P., Tucker, Stephen J., Baukrowitz, Thomas
Formato: Texto
Lenguaje:English
Publicado: Cell Press 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1950231/
https://www.ncbi.nlm.nih.gov/pubmed/17698013
http://dx.doi.org/10.1016/j.neuron.2007.07.026