Distinguishing Functional Amino Acid Covariation from Background Linkage Disequilibrium in HIV Protease and Reverse Transcriptase

Correlated amino acid mutation analysis has been widely used to infer functional interactions between different sites in a protein. However, this analysis can be confounded by important phylogenetic effects broadly classifiable as background linkage disequilibrium (BLD). We have systematically separ...

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Detalles Bibliográficos
Autores principales: Wang, Qi, Lee, Christopher
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1950573/
https://www.ncbi.nlm.nih.gov/pubmed/17726544
http://dx.doi.org/10.1371/journal.pone.0000814

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1950573/
https://www.ncbi.nlm.nih.gov/pubmed/17726544
http://dx.doi.org/10.1371/journal.pone.0000814

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