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Synthesis of two potential NK(1)-receptor ligands using [1-(11)C]ethyl iodide and [1-(11)C]propyl iodide and initial PET-imaging
BACKGROUND: The previously validated NK(1)-receptor ligand [O-methyl-(11)C]GR205171 binds with a high affinity to the NK(1)-receptor and displays a slow dissociation from the receptor. Hence, it cannot be used in vivo for detecting concentration changes in substance P, the endogenous ligand for the...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2007
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1959516/ https://www.ncbi.nlm.nih.gov/pubmed/17663770 http://dx.doi.org/10.1186/1471-2342-7-6 |