Therapeutic potential of analogues of amiloride: inhibition of the regulation of intracellular pH as a possible mechanism of tumour selective therapy.

The extracellular pH (pHe) in solid tumours is frequently lower than the pHe in normal tissues. Cells within an acidic environment depend on mechanisms which regulate intracellular pH (pHi) for their survival, including the Na+/H+ antiport which exports protons in exchange for Na+ ions. Amiloride an...

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Detalles Bibliográficos
Autores principales: Maidorn, R. P., Cragoe, E. J., Tannock, I. F.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1993
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968161/
https://www.ncbi.nlm.nih.gov/pubmed/8381657

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968161/
https://www.ncbi.nlm.nih.gov/pubmed/8381657

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