Dosage and cycle effects of dacarbazine (DTIC) and fotemustine on O6-alkylguanine-DNA alkyltransferase in human peripheral blood mononuclear cells.

There is increasing experimental evidence to suggest that endogenous expression of O6-alkylguanine-DNA-alkyltransferase (ATase) is a major factor in cellular resistance to certain chemotherapeutic agents including dacarbazine (DTIC). We have recently shown wide interindividual variation in the deple...

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Detalles Bibliográficos
Autores principales: Lee, S. M., Thatcher, N., Dougal, M., Margison, G. P.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1993
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968172/
https://www.ncbi.nlm.nih.gov/pubmed/8431354

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968172/
https://www.ncbi.nlm.nih.gov/pubmed/8431354

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