Molecular mechanisms of SR 4233-induced hepatocyte toxicity under aerobic versus hypoxic conditions.

SR 4233 (3-amino-1,2,4-benzotriazine-1,4-dioxide) is the lead compound of the benzotriazene-di-N oxides which are selectively toxic to tumour cells under hypoxic conditions. However much higher concentrations given to rats caused bone marrow toxicity and necrosis of the low oxygen Zone 3 part of the...

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Detalles Bibliográficos
Autores principales: Silva, J. M., O'Brien, P. J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1993
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968404/
https://www.ncbi.nlm.nih.gov/pubmed/8394729

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968404/
https://www.ncbi.nlm.nih.gov/pubmed/8394729

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