Cargando…
Multivariate analysis of prognostic factors in patients with non HIV-related primary cerebral lymphoma. A proposal for a prognostic scoring.
Between 1982 and 1991, 41 patients were treated for non HIV related primary cerebral lymphoma (PCL) in our institute. The purpose of this study was to perform a multivariate analysis of prognostic factors for survival in these patients. The presence of a CSF protein level over 0.6 g l-1 at diagnosis...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
1993
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968460/ https://www.ncbi.nlm.nih.gov/pubmed/8494713 |
_version_ | 1782134744897552384 |
---|---|
author | Blay, J. Y. Lasset, C. Carrie, C. Chauvin, F. Coiffier, B. Gisselbrecht, C. Clavel, M. Rebattu, P. Brunat-Mentigny, M. Philip, T. |
author_facet | Blay, J. Y. Lasset, C. Carrie, C. Chauvin, F. Coiffier, B. Gisselbrecht, C. Clavel, M. Rebattu, P. Brunat-Mentigny, M. Philip, T. |
author_sort | Blay, J. Y. |
collection | PubMed |
description | Between 1982 and 1991, 41 patients were treated for non HIV related primary cerebral lymphoma (PCL) in our institute. The purpose of this study was to perform a multivariate analysis of prognostic factors for survival in these patients. The presence of a CSF protein level over 0.6 g l-1 at diagnosis was found to be the most significant unfavourable prognostic factor in univariate analysis and had not previously been reported. Among the five significant prognostic factors at diagnosis, (age over 60 years, performance status--ECOG scale--over 2, memory dysfunction, non hemispheric tumour site, CSF protein level over 0.6 g l-1 at the diagnosis), three independent factors were identified in multivariate analysis: (1) CSF protein level (P = 0.007; RR = 4.7); (2) PS > 2 (P = 0.04, RR = 2.65); (3) age over 60 (P = 0.08; RR = 2.43). Using the regression coefficient of these three parameters, we determined a prognostic index which allowed us to distinguish three risk groups whose theoretical median survival is 4, 20 and 54, months respectively in patients with non HIV related PCL. These results indicate that PCL is an heterogeneous disease in terms of the prognostic in which three subgroups with discriminant survival can be identified. |
format | Text |
id | pubmed-1968460 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1993 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-19684602009-09-10 Multivariate analysis of prognostic factors in patients with non HIV-related primary cerebral lymphoma. A proposal for a prognostic scoring. Blay, J. Y. Lasset, C. Carrie, C. Chauvin, F. Coiffier, B. Gisselbrecht, C. Clavel, M. Rebattu, P. Brunat-Mentigny, M. Philip, T. Br J Cancer Research Article Between 1982 and 1991, 41 patients were treated for non HIV related primary cerebral lymphoma (PCL) in our institute. The purpose of this study was to perform a multivariate analysis of prognostic factors for survival in these patients. The presence of a CSF protein level over 0.6 g l-1 at diagnosis was found to be the most significant unfavourable prognostic factor in univariate analysis and had not previously been reported. Among the five significant prognostic factors at diagnosis, (age over 60 years, performance status--ECOG scale--over 2, memory dysfunction, non hemispheric tumour site, CSF protein level over 0.6 g l-1 at the diagnosis), three independent factors were identified in multivariate analysis: (1) CSF protein level (P = 0.007; RR = 4.7); (2) PS > 2 (P = 0.04, RR = 2.65); (3) age over 60 (P = 0.08; RR = 2.43). Using the regression coefficient of these three parameters, we determined a prognostic index which allowed us to distinguish three risk groups whose theoretical median survival is 4, 20 and 54, months respectively in patients with non HIV related PCL. These results indicate that PCL is an heterogeneous disease in terms of the prognostic in which three subgroups with discriminant survival can be identified. Nature Publishing Group 1993-05 /pmc/articles/PMC1968460/ /pubmed/8494713 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Research Article Blay, J. Y. Lasset, C. Carrie, C. Chauvin, F. Coiffier, B. Gisselbrecht, C. Clavel, M. Rebattu, P. Brunat-Mentigny, M. Philip, T. Multivariate analysis of prognostic factors in patients with non HIV-related primary cerebral lymphoma. A proposal for a prognostic scoring. |
title | Multivariate analysis of prognostic factors in patients with non HIV-related primary cerebral lymphoma. A proposal for a prognostic scoring. |
title_full | Multivariate analysis of prognostic factors in patients with non HIV-related primary cerebral lymphoma. A proposal for a prognostic scoring. |
title_fullStr | Multivariate analysis of prognostic factors in patients with non HIV-related primary cerebral lymphoma. A proposal for a prognostic scoring. |
title_full_unstemmed | Multivariate analysis of prognostic factors in patients with non HIV-related primary cerebral lymphoma. A proposal for a prognostic scoring. |
title_short | Multivariate analysis of prognostic factors in patients with non HIV-related primary cerebral lymphoma. A proposal for a prognostic scoring. |
title_sort | multivariate analysis of prognostic factors in patients with non hiv-related primary cerebral lymphoma. a proposal for a prognostic scoring. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968460/ https://www.ncbi.nlm.nih.gov/pubmed/8494713 |
work_keys_str_mv | AT blayjy multivariateanalysisofprognosticfactorsinpatientswithnonhivrelatedprimarycerebrallymphomaaproposalforaprognosticscoring AT lassetc multivariateanalysisofprognosticfactorsinpatientswithnonhivrelatedprimarycerebrallymphomaaproposalforaprognosticscoring AT carriec multivariateanalysisofprognosticfactorsinpatientswithnonhivrelatedprimarycerebrallymphomaaproposalforaprognosticscoring AT chauvinf multivariateanalysisofprognosticfactorsinpatientswithnonhivrelatedprimarycerebrallymphomaaproposalforaprognosticscoring AT coiffierb multivariateanalysisofprognosticfactorsinpatientswithnonhivrelatedprimarycerebrallymphomaaproposalforaprognosticscoring AT gisselbrechtc multivariateanalysisofprognosticfactorsinpatientswithnonhivrelatedprimarycerebrallymphomaaproposalforaprognosticscoring AT clavelm multivariateanalysisofprognosticfactorsinpatientswithnonhivrelatedprimarycerebrallymphomaaproposalforaprognosticscoring AT rebattup multivariateanalysisofprognosticfactorsinpatientswithnonhivrelatedprimarycerebrallymphomaaproposalforaprognosticscoring AT brunatmentignym multivariateanalysisofprognosticfactorsinpatientswithnonhivrelatedprimarycerebrallymphomaaproposalforaprognosticscoring AT philipt multivariateanalysisofprognosticfactorsinpatientswithnonhivrelatedprimarycerebrallymphomaaproposalforaprognosticscoring |