Interleukin-6 cDNA transfected Lewis lung carcinoma cells show unaltered net tumour growth rate but cause weight loss and shortened survival in syngeneic mice.

HuIL-6 cDNA, cloned into a neomycin resistant conferring expression vector, BMGNeo, was transfected into Lewis Lung Carcinoma (LLC) cells. LLC cells (5 x 10(6) ml-1) transfected with IL-6 cDNA (LLC-IL6) secreted IL-6 into the culture supernatant at a concentration of 9.9 ng ml-1 within 48 h. When 1,...

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Detalles Bibliográficos
Autores principales: Ohe, Y., Podack, E. R., Olsen, K. J., Miyahara, Y., Miura, K., Saito, H., Koishihara, Y., Ohsugi, Y., Ohira, T., Nishio, K.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1993
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968462/
https://www.ncbi.nlm.nih.gov/pubmed/8494727

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968462/
https://www.ncbi.nlm.nih.gov/pubmed/8494727

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