Pharmacokinetic studies in mice with ICI D0490, a novel recombinant ricin A-chain immunotoxin.

A colorectal tumour-directed immunotoxin, ICI D0490, has been constructed by linking recombinant ricin A-chain to C242, a mouse monoclonal antibody, by means of a methyl-hindered disulphide bond. Recombinant ricin A-chain and a hindered disulphide linker were anticipated to confer favourable pharmac...

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Detalles Bibliográficos
Autores principales: Calvete, J. A., Newell, D. R., Charlton, C. J., Wright, A. F.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1993
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968515/
https://www.ncbi.nlm.nih.gov/pubmed/8512816

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968515/
https://www.ncbi.nlm.nih.gov/pubmed/8512816

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