Calmodulin inhibitor trifluoperazine in combination with doxorubicin induces the selection of tumour cells with the multidrug resistant phenotype.

Trifluoperazine (TFP) is effective in modulating DNA damage/repair in doxorubicin (DOX) treated cells. In the present study we have characterised the resistance phenotype of parental sensitive L1210 mouse leukaemia cells (L1210/S) adapted to grow in the presence of 0.017 microns DOX+5 microM TFP (L1...

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Detalles Bibliográficos
Autores principales: Kamath, N., Grabowski, D., Ford, J., Ganapathi, R.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1993
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968516/
https://www.ncbi.nlm.nih.gov/pubmed/8099806

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968516/
https://www.ncbi.nlm.nih.gov/pubmed/8099806

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