Enhancement of sensitivity to platinum(II)-containing drugs by 12-O-tetradecanoyl-phorbol-13-acetate in a human ovarian carcinoma cell line.

Sensitivity to platinum-containing drugs is believed to be a function of how much drug enters the cell, the extent of DNA adduct formation and the rate at which DNA is repaired. Activation of protein kinase C by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) was found to enhance the sensitivity of huma...

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Detalles Bibliográficos
Autores principales: Isonishi, S., Hom, D. K., Eastman, A., Howell, S. B.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1994
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968705/
https://www.ncbi.nlm.nih.gov/pubmed/8297717

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968705/
https://www.ncbi.nlm.nih.gov/pubmed/8297717

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