A novel cell-based assay for the evaluation of anti-ras compounds.

In order to identify drugs active against mutated ras oncogenes we have developed an in vitro assay employing two clones of the human fibrosarcoma cell-line, HT1080 which carries an N-ras gene mutated at codon 61. Clone, HT1080scc2, retains the transformed phenotype of the parental line, whilst the...

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Detalles Bibliográficos
Autores principales: Jenkins, D. C., Stables, J. N., Wilkinson, J., Topley, P., Holmes, L. S., Linstead, D. J., Rapson, E. B.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1993
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968724/
https://www.ncbi.nlm.nih.gov/pubmed/8217601

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968724/
https://www.ncbi.nlm.nih.gov/pubmed/8217601

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