Mechanism of action of an orally administered platinum complex [ammine bis butyrato cyclohexylamine dichloroplatinum (IV) (JM221)] in intrinsically cisplatin-resistant human ovarian carcinoma in vitro.

Intrinsic resistance to existing clinical platinum drugs is a major cause of treatment failure; moreover, these agents have the drawbacks of cross-resistance and intravenous administration. The mechanism of intrinsic cisplatin resistance and the mechanism of circumvention of intrinsic resistance by...

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Detalles Bibliográficos
Autores principales: McKeage, M. J., Abel, G., Kelland, L. R., Harrap, K. R.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1994
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968778/
https://www.ncbi.nlm.nih.gov/pubmed/8286188

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968778/
https://www.ncbi.nlm.nih.gov/pubmed/8286188

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