Pharmacokinetic-dynamic relationship of cisplatin in vitro: simulation of an i.v. bolus and 3 h and 20 h infusion.

The profiles of an i.v. bolus and 3 h and 20 h infusion of cisplatin (CDDP) were simulated in vitro by using a culture of the IGROV1 human ovarian cancer cell line. Disappearance of pharmacologically active unbound CDDP was accomplished by adding human albumin to the medium. Total and unbound CDDP a...

Descripción completa

Detalles Bibliográficos
Autores principales: Ma, J., Verweij, J., Kolker, H. J., van Ingen, H. E., Stoter, G., Schellens, J. H.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1994
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968910/
https://www.ncbi.nlm.nih.gov/pubmed/8180014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968910/
https://www.ncbi.nlm.nih.gov/pubmed/8180014

Ejemplares similares