Selective toxicity of TGF-alpha-PE40 to EGFR-positive cell lines: selective protection of low EGFR-expressing cell lines by EGF.

The sensitivity of human breast and lung cancer cell lines to TGF-alpha-PE40, a novel chimeric recombinant cytotoxin composed of two independent domains, (i) TGF-alpha and (ii) a 40 kDa segment of the Pseudomonas exotoxin protein, PE-40, was investigated. Toxicity varied widely, correlated with epid...

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Detalles Bibliográficos
Autores principales: Kirk, J., Carmichael, J., Stratford, I. J., Harris, A. L.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1994
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1969441/
https://www.ncbi.nlm.nih.gov/pubmed/8198991

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1969441/
https://www.ncbi.nlm.nih.gov/pubmed/8198991

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