The formation and removal of cisplatin (CDDP) induced DNA adducts in a CDDP sensitive and resistant human small cell lung carcinoma (HSCLC) cell line.

In DNA digested samples of CDDP sensitive (GLC4) and an 11-fold resistant (GLC4-CDDP) hSCLC line, the CDDP induced DNA adducts Pt-GG (Pt-(NH3)2d (pGpG], Pt-AG (Pt-(NH3)2d (pApG], G-Pt-G (Pt-(NH3)2d (GMP)2) and Pt-GMP (Pt-(NH3)3d GMP), were measured with polyclonal antibodies. The total amount of pla...

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Detalles Bibliográficos
Autores principales: Hospers, G. A., de Vries, E. G., Mulder, N. H.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1990
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971318/
https://www.ncbi.nlm.nih.gov/pubmed/2153398

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971318/
https://www.ncbi.nlm.nih.gov/pubmed/2153398

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