Pharmacokinetic studies with the antifolate C2-desamino-C2-methyl-N10-propargyl-2'-trifluoromethyl-5,8-dideazafolic acid (CB3988) in mice and rats using in vivo 19F-NMR spectroscopy.

In vivo 19F-NMR spectroscopy has been used to study the pharmacokinetics of the experimental antifolate drug CB3988 (C2-desamino-C2-methyl-N10-propargyl-2'trifluoromethyl-5,8-dideazafolic acid) in mice and rats. NMR results have been compared to those obtained by HPLC and the effect of the incl...

Descripción completa

Detalles Bibliográficos
Autores principales: Newell, D. R., Maxwell, R. J., Bisset, G. M., Jodrell, D. I., Griffiths, J. R.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1990
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971528/
https://www.ncbi.nlm.nih.gov/pubmed/2245168

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971528/
https://www.ncbi.nlm.nih.gov/pubmed/2245168

Ejemplares similares