Ploidy as a prognostic indicator in end stage squamous cell carcinoma of the head and neck region treated with cisplatinum.

We measured tumour cellular DNA in 102 patients entered into two phase III trials of chemotherapy for end stage squamous carcinoma of the head and neck. The median survival of untreated patients with aneuploid tumours was 55 days compared with 224 days for patients treated with cisplatinum. This dif...

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Detalles Bibliográficos
Autores principales: Cooke, L. D., Cooke, T. G., Bootz, F., Forster, G., Helliwell, T. R., Spiller, D., Stell, P. M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1990
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971589/
https://www.ncbi.nlm.nih.gov/pubmed/2337512
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author Cooke, L. D.
Cooke, T. G.
Bootz, F.
Forster, G.
Helliwell, T. R.
Spiller, D.
Stell, P. M.
author_facet Cooke, L. D.
Cooke, T. G.
Bootz, F.
Forster, G.
Helliwell, T. R.
Spiller, D.
Stell, P. M.
author_sort Cooke, L. D.
collection PubMed
description We measured tumour cellular DNA in 102 patients entered into two phase III trials of chemotherapy for end stage squamous carcinoma of the head and neck. The median survival of untreated patients with aneuploid tumours was 55 days compared with 224 days for patients treated with cisplatinum. This difference was highly significant. In contrast the median survival of untreated patients with diploid tumours was 74 days compared with 118 days for treated patients. Although this difference is statistically significant, the increased survival of 6 weeks is of no clinical benefit compared with the prolongation of survival of 6 months in patients with aneuploid tumours. Multivariate analysis showed that the significant predictors of survival were Karnofsky status, response to chemotherapy and ploidy.
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spelling pubmed-19715892009-09-10 Ploidy as a prognostic indicator in end stage squamous cell carcinoma of the head and neck region treated with cisplatinum. Cooke, L. D. Cooke, T. G. Bootz, F. Forster, G. Helliwell, T. R. Spiller, D. Stell, P. M. Br J Cancer Research Article We measured tumour cellular DNA in 102 patients entered into two phase III trials of chemotherapy for end stage squamous carcinoma of the head and neck. The median survival of untreated patients with aneuploid tumours was 55 days compared with 224 days for patients treated with cisplatinum. This difference was highly significant. In contrast the median survival of untreated patients with diploid tumours was 74 days compared with 118 days for treated patients. Although this difference is statistically significant, the increased survival of 6 weeks is of no clinical benefit compared with the prolongation of survival of 6 months in patients with aneuploid tumours. Multivariate analysis showed that the significant predictors of survival were Karnofsky status, response to chemotherapy and ploidy. Nature Publishing Group 1990-05 /pmc/articles/PMC1971589/ /pubmed/2337512 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Cooke, L. D.
Cooke, T. G.
Bootz, F.
Forster, G.
Helliwell, T. R.
Spiller, D.
Stell, P. M.
Ploidy as a prognostic indicator in end stage squamous cell carcinoma of the head and neck region treated with cisplatinum.
title Ploidy as a prognostic indicator in end stage squamous cell carcinoma of the head and neck region treated with cisplatinum.
title_full Ploidy as a prognostic indicator in end stage squamous cell carcinoma of the head and neck region treated with cisplatinum.
title_fullStr Ploidy as a prognostic indicator in end stage squamous cell carcinoma of the head and neck region treated with cisplatinum.
title_full_unstemmed Ploidy as a prognostic indicator in end stage squamous cell carcinoma of the head and neck region treated with cisplatinum.
title_short Ploidy as a prognostic indicator in end stage squamous cell carcinoma of the head and neck region treated with cisplatinum.
title_sort ploidy as a prognostic indicator in end stage squamous cell carcinoma of the head and neck region treated with cisplatinum.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971589/
https://www.ncbi.nlm.nih.gov/pubmed/2337512
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