Inactivation and clearance of an anti-CEA carboxypeptidase G2 conjugate in blood after localisation in a xenograft model.

Studies with a conjugate of carboxypeptidase G2 (CPG2) and the F(ab')2 fragment of monoclonal anti-CEA antibody, A5B7, have shown specific localisation in a human colon tumour xenograft, LS174T, growing in nude mice. The conjugate reaches a peak concentration in the tumour within 24 h but enzym...

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Detalles Bibliográficos
Autores principales: Sharma, S. K., Bagshawe, K. D., Burke, P. J., Boden, R. W., Rogers, G. T.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1990
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971605/
https://www.ncbi.nlm.nih.gov/pubmed/2337503

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971605/
https://www.ncbi.nlm.nih.gov/pubmed/2337503

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