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Glutathione diminishes the anti-tumour activity of 4-hydroperoxycyclophosphamide by stabilising its spontaneous breakdown to alkylating metabolites.
Evidence was obtained showing that GSH protects against the cytotoxicity of 4-hydroperoxycyclophosphamide (4-OOH-CP) by minimizing the spontaneous fission of 4-hydroxycyclophosphamide (4-OH-CP), its breakdown product, to the ultimate toxic species, phosphoramide mustard (PM). This conclusion was bor...
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| Formato: | Texto |
| Lenguaje: | English |
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Nature Publishing Group
1991
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971657/ https://www.ncbi.nlm.nih.gov/pubmed/1989664 |