Comparative effect of 6S, 6R and 6RS leucovorin on methotrexate rescue and on modulation of 5-fluorouracil.

The comparative efficacy of the pure diastereoisomers of leucovorin, the natural (6S) and the unnatural (6R) forms was compared to the racemic form (6RS). A protective effect in methotrexate-treated CCRF-CEM cells was obtained with 6S at concentrations 100-fold higher than those of methotrexate and...

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Detalles Bibliográficos
Autores principales: Zittoun, J., Marquet, J., Pilorget, J. J., Tonetti, C., De Gialluly, E.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1991
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1972534/
https://www.ncbi.nlm.nih.gov/pubmed/2069845

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1972534/
https://www.ncbi.nlm.nih.gov/pubmed/2069845

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