Structural Reorganisation and Potential Toxicity of Oligomeric Species Formed during the Assembly of Amyloid Fibrils

Increasing evidence indicates that oligomeric protein assemblies may represent the molecular species responsible for cytotoxicity in a range of neurological disorders including Alzheimer and Parkinson diseases. We use all-atom computer simulations to reveal that the process of oligomerization can be...

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Detalles Bibliográficos
Autores principales: Cheon, Mookyung, Chang, Iksoo, Mohanty, Sandipan, Luheshi, Leila M, Dobson, Christopher M, Vendruscolo, Michele, Favrin, Giorgio
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976335/
https://www.ncbi.nlm.nih.gov/pubmed/17941703
http://dx.doi.org/10.1371/journal.pcbi.0030173

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976335/
https://www.ncbi.nlm.nih.gov/pubmed/17941703
http://dx.doi.org/10.1371/journal.pcbi.0030173

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