Polymerase-catalyzed synthesis of DNA from phosphoramidate conjugates of deoxynucleotides and amino acids

Some selected amino acids, in particular l-aspartic acid (l-Asp) and l-histidine (l-His), can function as leaving group during polymerase-catalyzed incorporation of deoxyadenosine monophosphate (dAMP) in DNA. Although l-Asp-dAMP and l-His-dAMP bind, most probably, in a different way in the active si...

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Detalles Bibliográficos
Autores principales: Adelfinskaya, O., Terrazas, M., Froeyen, M., Marlière, P., Nauwelaerts, K., Herdewijn, P.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2007
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976459/
https://www.ncbi.nlm.nih.gov/pubmed/17652326
http://dx.doi.org/10.1093/nar/gkm498

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976459/
https://www.ncbi.nlm.nih.gov/pubmed/17652326
http://dx.doi.org/10.1093/nar/gkm498

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