Active site binding and sequence requirements for inhibition of HIV-1 reverse transcriptase by the RT1 family of single-stranded DNA aptamers

Nucleic acid aptamers can potentially be developed as broad-spectrum antiviral agents. Single-stranded DNA (ssDNA) aptamer RT1t49 inhibits reverse transcriptases (RT) from HIV-1 and diverse lentiviral subtypes with low nanomolar values of Kd and IC(50). To dissect the structural requirements for inh...

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Detalles Bibliográficos
Autores principales: Kissel, Jay D., Held, Daniel M., Hardy, Richard W., Burke, Donald H.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2007
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976467/
https://www.ncbi.nlm.nih.gov/pubmed/17644816
http://dx.doi.org/10.1093/nar/gkm420

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976467/
https://www.ncbi.nlm.nih.gov/pubmed/17644816
http://dx.doi.org/10.1093/nar/gkm420

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