Constitutive Phosphorylation of Aurora-A on Ser51 Induces Its Stabilization and Consequent Overexpression in Cancer

BACKGROUND: The serine/threonine kinase Aurora-A (Aur-A) is a proto-oncoprotein overexpressed in a wide range of human cancers. Overexpression of Aur-A is thought to be caused by gene amplification or mRNA overexpression. However, recent evidence revealed that the discrepancies between amplification...

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Detalles Bibliográficos
Autores principales: Kitajima, Shojiro, Kudo, Yasusei, Ogawa, Ikuko, Tatsuka, Masaaki, Kawai, Hidehiko, Pagano, Michele, Takata, Takashi
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976594/
https://www.ncbi.nlm.nih.gov/pubmed/17895985
http://dx.doi.org/10.1371/journal.pone.0000944

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976594/
https://www.ncbi.nlm.nih.gov/pubmed/17895985
http://dx.doi.org/10.1371/journal.pone.0000944

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