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Defective responses of transformed keratinocytes to terminal differentiation stimuli. Their role in epidermal tumour promotion by phorbol esters and by deep skin wounding.
Epidermal tumourigenesis can be achieved in rodents by the application of a single subthreshold dose of a carcinogen (initiation) followed by repeated applications of a tumour promoter such as 12-0-tetradecanoyl phorbol, 13-acetate (TPA). TPA induces terminal differentiation in the majority of epide...
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| Formato: | Texto |
| Lenguaje: | English |
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Nature Publishing Group
1985
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977240/ https://www.ncbi.nlm.nih.gov/pubmed/2415144 |