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Tumour localisation with a radioactively labelled reshaped human monoclonal antibody.
A genetically reshaped human IgG1 monoclonal antibody (Hu2PLAP) with anti-tumour specificity, was radiolabelled with Indium-111 by chelation with a new macrocyclic compound (DOTA) which allows the production of stable radioimmunoconjugates for in vivo application. This was used to image seven patien...
Autores principales: | , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
1991
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977456/ https://www.ncbi.nlm.nih.gov/pubmed/1931615 |
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author | Hird, V. Verhoeyen, M. Badley, R. A. Price, D. Snook, D. Kosmas, C. Gooden, C. Bamias, A. Meares, C. Lavender, J. P. |
author_facet | Hird, V. Verhoeyen, M. Badley, R. A. Price, D. Snook, D. Kosmas, C. Gooden, C. Bamias, A. Meares, C. Lavender, J. P. |
author_sort | Hird, V. |
collection | PubMed |
description | A genetically reshaped human IgG1 monoclonal antibody (Hu2PLAP) with anti-tumour specificity, was radiolabelled with Indium-111 by chelation with a new macrocyclic compound (DOTA) which allows the production of stable radioimmunoconjugates for in vivo application. This was used to image seven patients with malignant disease, of whom two had been previously exposed to mouse monoclonal antibodies and had developed human anti-mouse antibodies (HAMA). Successful tumour localisation was seen in the four patients with active disease and antigen positive tumours. No patient showed any antibody responses against Hu2PLAP, but three out of six patients tested showed an immune response against the macrocycle DOTA. Reshaped human monoclonal antibodies with anti-tumour specificity may facilitate repeated administrations of radioactive antibodies, thus allowing new possibilities, both in the diagnosis and treatment of cancer. IMAGES: |
format | Text |
id | pubmed-1977456 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1991 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-19774562009-09-10 Tumour localisation with a radioactively labelled reshaped human monoclonal antibody. Hird, V. Verhoeyen, M. Badley, R. A. Price, D. Snook, D. Kosmas, C. Gooden, C. Bamias, A. Meares, C. Lavender, J. P. Br J Cancer Research Article A genetically reshaped human IgG1 monoclonal antibody (Hu2PLAP) with anti-tumour specificity, was radiolabelled with Indium-111 by chelation with a new macrocyclic compound (DOTA) which allows the production of stable radioimmunoconjugates for in vivo application. This was used to image seven patients with malignant disease, of whom two had been previously exposed to mouse monoclonal antibodies and had developed human anti-mouse antibodies (HAMA). Successful tumour localisation was seen in the four patients with active disease and antigen positive tumours. No patient showed any antibody responses against Hu2PLAP, but three out of six patients tested showed an immune response against the macrocycle DOTA. Reshaped human monoclonal antibodies with anti-tumour specificity may facilitate repeated administrations of radioactive antibodies, thus allowing new possibilities, both in the diagnosis and treatment of cancer. IMAGES: Nature Publishing Group 1991-11 /pmc/articles/PMC1977456/ /pubmed/1931615 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Research Article Hird, V. Verhoeyen, M. Badley, R. A. Price, D. Snook, D. Kosmas, C. Gooden, C. Bamias, A. Meares, C. Lavender, J. P. Tumour localisation with a radioactively labelled reshaped human monoclonal antibody. |
title | Tumour localisation with a radioactively labelled reshaped human monoclonal antibody. |
title_full | Tumour localisation with a radioactively labelled reshaped human monoclonal antibody. |
title_fullStr | Tumour localisation with a radioactively labelled reshaped human monoclonal antibody. |
title_full_unstemmed | Tumour localisation with a radioactively labelled reshaped human monoclonal antibody. |
title_short | Tumour localisation with a radioactively labelled reshaped human monoclonal antibody. |
title_sort | tumour localisation with a radioactively labelled reshaped human monoclonal antibody. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977456/ https://www.ncbi.nlm.nih.gov/pubmed/1931615 |
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