Enhanced 5-fluorouracil cytotoxicity and elevated 5-fluoronucleotides in the rat Walker carcinosarcoma following methotrexate pre-treatment: a 19F-MRS study in vivo.

5-fluorouracil (5FU) is activated intracellularly to cytotoxic 5-fluoronucleotides (FNuct). These were detected non-invasively in rats bearing the Walker carcinosarcoma by 19F-magnetic resonance spectroscopy (MRS) following an i.v. bolus dose of 5FU (50 mg kg-1). Pre-treatment of the rats (3 to 24 h...

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Detalles Bibliográficos
Autores principales: McSheehy, P. M., Prior, M. J., Griffiths, J. R.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1992
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977582/
https://www.ncbi.nlm.nih.gov/pubmed/1558790

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977582/
https://www.ncbi.nlm.nih.gov/pubmed/1558790

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