Cargando…

Enhanced 5-fluorouracil cytotoxicity and elevated 5-fluoronucleotides in the rat Walker carcinosarcoma following methotrexate pre-treatment: a 19F-MRS study in vivo.

5-fluorouracil (5FU) is activated intracellularly to cytotoxic 5-fluoronucleotides (FNuct). These were detected non-invasively in rats bearing the Walker carcinosarcoma by 19F-magnetic resonance spectroscopy (MRS) following an i.v. bolus dose of 5FU (50 mg kg-1). Pre-treatment of the rats (3 to 24 h...

Descripción completa

Detalles Bibliográficos
Autores principales:	McSheehy, P. M., Prior, M. J., Griffiths, J. R.
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 1992
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977582/ https://www.ncbi.nlm.nih.gov/pubmed/1558790

Ejemplares similares

Prediction of 5-fluorouracil cytotoxicity towards the Walker carcinosarcoma using peak integrals of fluoronucleotides measured by MRS in vivo.
por: McSheehy, P. M., et al.
Publicado: (1989)

Metabolism of 5-methyltetrahydrofolate by rats bearing the Walker 256 carcinosarcoma.
por: Kennelly, J. C., et al.
Publicado: (1982)

In vivo detection of ifosfamide by 31P-MRS in rat tumours: increased uptake and cytotoxicity induced by carbogen breathing in GH3 prolactinomas.
por: Rodrigues, L. M., et al.
Publicado: (1997)

Influence of pH on the uptake of 5-fluorouracil into isolated tumour cells.
por: Ojugo, A. S., et al.
Publicado: (1998)

Aprotinin and growth of Walker 256 carcinosarcoma in the rat.
por: Thomson, A. W., et al.
Publicado: (1977)

Fluorene derivatives in rats bearing Walker carcinosarcoma.
por: Malejka, D.
Publicado: (1965)

The Development of Resistance in the Walker Carcinosarcoma to the Action of Triethylene Melamine
por: Jackson, H.
Publicado: (1954)

Prostaglandin E production and hypercalcaemia in rats bearing the Walker carcinosarcoma
por: Seyberth, H. W., et al.
Publicado: (1980)

The Influence of Walker 256 Carcinosarcoma on the Metabolism of Corticosterone and Androstenolone in Rats
por: King, R. J. B., et al.
Publicado: (1963)

Ascorbic acid inhibits the migration of walker 256 carcinosarcoma cells
por: Wybieralska, Ewa, et al.
Publicado: (2007)

Distribution of new fluorene disulphonamido derivatives in rats with transplanted Walker carcinosarcoma.
por: Malejka, D.
Publicado: (1966)

Mechanism of Metabolic Abnormality of Thyroid Hormones in Walker 256 Carcinosarcoma‐bearing Rats
por: Murayama‐Oda, Kikuno, et al.
Publicado: (1991)

Impact of elastic substrate on the dynamic heterogeneity of WC256 Walker carcinosarcoma cells
por: Mielnicka, Aleksandra, et al.
Publicado: (2023)

Comparison of CVF (Cyclophosphamide+Vinorelbine+5-Fluorouracil) and CMF (Cyclophosphamide+Methotrexate+5-Fluorouracil) Adjuvant Chemotherapy in Early Breast Cancer
por: Gwak, Geumhee, et al.
Publicado: (2011)

Failure of systemic ketosis to control cachexia and the growth rate of the Walker 256 carcinosarcoma in rats.
por: Fearon, K. C., et al.
Publicado: (1985)

Cyclophosphamide, methotrexate and infusional 5-fluorouracil (infusional CMF) in metastatic breast cancer.
por: O'Byrne, K. J., et al.
Publicado: (1998)

Fluorouracil Catabolism in the Combination Treatment of Cyclophosphamide, Methotrexate and Fluorouracil
por: De Bruijn, Ernst A., et al.
Publicado: (1992)

Preoperative chemotherapy with docetaxel, cisplatin, and 5-fluorouracil for locally advanced esophageal carcinosarcoma: a case report and review of the literature
por: Yoshimoto, Tomoko, et al.
Publicado: (2018)

Circadian variations in 32P uptake of DMBA-induced mammary tumour and Walker carcinosarcoma in rats.
por: Møoller, U., et al.
Publicado: (1976)

In vivo interaction of anti-cancer drugs with misonidazole or metronidazole: methotrexate, 5-fluorouracil and adriamycin.
por: Tannock, I. F.
Publicado: (1980)

In Vitro Release of 5-Fluorouracil and Methotrexate from Different Thermosensitive Chitosan Hydrogel Systems
por: Mohammed, Ahmed M., et al.
Publicado: (2020)

Adjuvant sequential methotrexate → 5-fluorouracil vs 5-fluorouracil plus leucovorin in radically resected stage III and high-risk stage II colon cancer
por: Sobrero, A, et al.
Publicado: (2005)

Adjuvant sequential methotrexate → 5-fluorouracil vs 5-fluorouracil plus leucovorin in radically resected stage III and high-risk stage II colon cancer
por: Sobrero, A, et al.
Publicado: (2005)

Randomized trial to compare the efficacy and toxicity of cyclophosphamide, methotrexate and 5-fluorouracil (CMF) with methotrexate mitoxantrone (MM) in advanced carcinoma of the breast
por: Harper-Wynne, C, et al.
Publicado: (1999)

Cytotoxicity and radiosensitising activity of synthesized dinitrophenyl derivatives of 5-fluorouracil
por: Abdi, Khosrou, et al.
Publicado: (2012)

Lamellipodia and Membrane Blebs Drive Efficient Electrotactic Migration of Rat Walker Carcinosarcoma Cells WC 256
por: Sroka, Jolanta, et al.
Publicado: (2016)

Enhancement of 5-fluorouracil-induced cytotoxicity by leucovorin in 5-fluorouracil-resistant gastric cancer cells with upregulated expression of thymidylate synthase
por: Nakamura, Ayako, et al.
Publicado: (2013)

The biology of large solid tumours regressing with nitrogen mustard treatment: a study of the mouse plasma cell tumour Adj-pc-5 and the Walker carcinosarcoma 256.
por: Goldacre, R. J., et al.
Publicado: (1966)

γ-Glutamyl hydrolase modulation and folate influence chemosensitivity of cancer cells to 5-fluorouracil and methotrexate
por: Kim, S-E, et al.
Publicado: (2013)

Pre-treatment assay of 5-fluorouracil degradation rate (5-FUDR) to improve prediction of 5-fluorouracil toxicity in gastro-esophageal cancer
por: Borro, Marina, et al.
Publicado: (2016)

Cadmium influences the 5-fluorouracil cytotoxic effects on breast cancer cells
por: Asara, Y., et al.
Publicado: (2012)

Synergistic enhancement of 5-fluorouracil cytotoxicity by deoxyuridine analogs in cancer cells
por: Matsumoto, Yoshihiro, et al.
Publicado: (2015)

Dose-intense weekly cyclophosphamide, methotrexate, 5-fluorouracil, vincristine and prednisolone (CMFP) in advanced breast cancer.
por: Cebon, J. S., et al.
Publicado: (1990)

Comparative effect of 6S, 6R and 6RS leucovorin on methotrexate rescue and on modulation of 5-fluorouracil.
por: Zittoun, J., et al.
Publicado: (1991)

Dietary polyphenols influence antimetabolite agents: methotrexate, 6-mercaptopurine and 5-fluorouracil in leukemia cell lines
por: Mahbub, Amani, et al.
Publicado: (2017)

UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation
por: Pettersen, Henrik Sahlin, et al.
Publicado: (2011)

Abscopal antitumor immune effects of magnet-mediated hyperthermia at a high therapeutic temperature on Walker-256 carcinosarcomas in rats
por: WANG, HUI, et al.
Publicado: (2014)

Physical PEGylation Enhances The Cytotoxicity Of 5-Fluorouracil-Loaded PLGA And PCL Nanoparticles
por: Ashour, Abdelkader E, et al.
Publicado: (2019)

5-fluorouracil modulated by leucovorin, methotrexate and mitomycin: highly effective, low-cost chemotherapy for advanced colorectal cancer
por: Sobrero, A, et al.
Publicado: (2001)

Phase II study of a triplet regimen in advanced colorectal cancer using methotrexate, oxaliplatin and 5-fluorouracil
por: Guglielmi, A, et al.
Publicado: (2004)

Cannot write session to /tmp/vufind_sessions/sess_dnji7ecc6mtj5evvek7iltu1tv