Molecular and functional characterisation of a fusion protein suited for tumour specific prodrug activation.

A fusion protein consisting of the humanised Fab fragment of the anti CEA MAb BW 431 and the human beta-glucuronidase was expressed in BHK cells. Functional testing revealed that the specificity and avidity of the humanised V region was similar to the original murine MAb BW 431. Furthermore, the enz...

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Detalles Bibliográficos
Autores principales: Bosslet, K., Czech, J., Lorenz, P., Sedlacek, H. H., Schuermann, M., Seemann, G.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1992
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977731/
https://www.ncbi.nlm.nih.gov/pubmed/1739623

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977731/
https://www.ncbi.nlm.nih.gov/pubmed/1739623

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