Synergism between a novel amphibian oocyte ribonuclease and lovastatin in inducing cytostatic and cytotoxic effects in human lung and pancreatic carcinoma cell lines.

A novel anti-tumour amphibian oocyte RNase, ONCONASER (ONC), previously known as P-30 Protein, is in the clinical trials. The effect of ONC alone and in combination with lovastatin (LVT), an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, a rate-limiting enzyme of mevalonate...

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Detalles Bibliográficos
Autores principales: Mikulski, S. M., Viera, A., Darzynkiewicz, Z., Shogen, K.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1992
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977805/
https://www.ncbi.nlm.nih.gov/pubmed/1503903

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977805/
https://www.ncbi.nlm.nih.gov/pubmed/1503903

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