The binding of cis-dichlorodiammineplatinum(II) to extracellular and intracellular compounds in relation to drug uptake and cytotoxicity in vitro.

The biological consequence of the binding of cis-dichlorodiammineplatinum(II) (cis-DDP) to serum protein as well as to cellular components in general, was studied on human NHIK 3025 cells in vitro. As expected, we found that the cytotoxicity of cis-DDP was lost by binding to serum protein, and that...

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Detalles Bibliográficos
Autores principales: Melvik, J. E., Dornish, J. M., Pettersen, E. O.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1992
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977828/
https://www.ncbi.nlm.nih.gov/pubmed/1503898

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977828/
https://www.ncbi.nlm.nih.gov/pubmed/1503898

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