A monoclonal antibody-beta-glucuronidase conjugate as activator of the prodrug epirubicin-glucuronide for specific treatment of cancer.

The anti-pan carcinoma monoclonal antibody (MAb) 323/A3, linked to E. coli-derived beta-glucuronidase (GUS) was used to study the tumour-site-selective activation of the prodrug Epirubicin-glucuronide (Epi-glu). Epi-glu was isolated from the urine of patients treated with Epirubicin (Epi) by reverse...

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Detalles Bibliográficos
Autores principales: Haisma, H. J., Boven, E., van Muijen, M., de Jong, J., van der Vijgh, W. J., Pinedo, H. M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1992
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977944/
https://www.ncbi.nlm.nih.gov/pubmed/1520585

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977944/
https://www.ncbi.nlm.nih.gov/pubmed/1520585

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