Reduced drug accumulation as a major mechanism of acquired resistance to cisplatin in a human ovarian carcinoma cell line: circumvention studies using novel platinum (II) and (IV) ammine/amine complexes.

Acquired resistance to cisplatin (cis-diamminedichloroplatinum (II)) has been generated in vitro in the 41M human ovarian carcinoma cell line, established from a previously untreated patient. Three cisplatin-resistant variants were selected at approximately 2, 4 and 6-fold resistance (in terms of 50...

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Detalles Bibliográficos
Autores principales: Loh, S. Y., Mistry, P., Kelland, L. R., Abel, G., Harrap, K. R.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1992
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1978040/
https://www.ncbi.nlm.nih.gov/pubmed/1457352

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1978040/
https://www.ncbi.nlm.nih.gov/pubmed/1457352

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