The TCF7L2 locus and type 1 diabetes

BACKGROUND: TCF7L2 belongs to a subfamily of TCF7-like HMG box-containing transcription factors, and maps to human chromosome 10q25.3. A recent study identified genetic association of type 2 diabetes (T2D) with this gene, correlated with diminished insulin secretion. This study aimed to investigate...

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Detalles Bibliográficos
Autores principales: Qu, Hui-Qi, Polychronakos, Constantin
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1978206/
https://www.ncbi.nlm.nih.gov/pubmed/17683561
http://dx.doi.org/10.1186/1471-2350-8-51
Descripción
Sumario:BACKGROUND: TCF7L2 belongs to a subfamily of TCF7-like HMG box-containing transcription factors, and maps to human chromosome 10q25.3. A recent study identified genetic association of type 2 diabetes (T2D) with this gene, correlated with diminished insulin secretion. This study aimed to investigate the possibility of genetic association between TCF7L2 and type 1 diabetes (T1D). METHODS: The SNP most significantly associated with T2D, rs7903146, was genotyped in 886 T1D nuclear family trios with ethnic backgrounds of mixed European descent. RESULTS: This study found no T1D association with, and no age-of-onset effect from rs7903146. CONCLUSION: This study suggests that a T2D mechanism mediated by TCF7L2 does not participate in the etiology of T1D.

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