Evidence that Proteasome-Dependent Degradation of the Retinoblastoma Protein in Cells Lacking A-Type Lamins Occurs Independently of Gankyrin and MDM2

BACKGROUND: A-type lamins, predominantly lamins A and C, are nuclear intermediate filaments believed to act as scaffolds for assembly of transcription factors. Lamin A/C is necessary for the retinoblastoma protein (pRB) stabilization through unknown mechanism(s). Two oncoproteins, gankyrin and MDM2,...

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Detalles Bibliográficos
Autores principales: Nitta, Ryan T., Smith, Catherine L., Kennedy, Brian K.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1978514/
https://www.ncbi.nlm.nih.gov/pubmed/17896003
http://dx.doi.org/10.1371/journal.pone.0000963

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1978514/
https://www.ncbi.nlm.nih.gov/pubmed/17896003
http://dx.doi.org/10.1371/journal.pone.0000963

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