Digital NFATc2 Activation per Cell Transforms Graded T Cell Receptor Activation into an All-or-None IL-2 Expression

The expression of interleukin-2 (IL-2) is a key event in T helper (Th) lymphocyte activation, controlling both, the expansion and differentiation of effector Th cells as well as the activation of regulatory T cells. We demonstrate that the strength of TCR stimulation is translated into the frequency...

Descripción completa

Detalles Bibliográficos
Autores principales: Podtschaske, Miriam, Benary, Uwe, Zwinger, Sandra, Höfer, Thomas, Radbruch, Andreas, Baumgrass, Ria
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1978524/
https://www.ncbi.nlm.nih.gov/pubmed/17895976
http://dx.doi.org/10.1371/journal.pone.0000935

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1978524/
https://www.ncbi.nlm.nih.gov/pubmed/17895976
http://dx.doi.org/10.1371/journal.pone.0000935

Ejemplares similares