The INT6 Cancer Gene and MEK Signaling Pathways Converge during Zebrafish Development

BACKGROUND: Int-6 (integration site 6) was identified as an oncogene in a screen of tumorigenic mouse mammary tumor virus (MMTV) insertions. INT6 expression is altered in human cancers, but the precise role of disrupted INT6 in tumorigenesis remains unclear, and an animal model to study Int-6 physio...

Descripción completa

Detalles Bibliográficos
Autores principales: Grzmil, Michal, Whiting, Danny, Maule, John, Anastasaki, Corina, Amatruda, James F., Kelsh, Robert N., Norbury, Chris J., Patton, E. Elizabeth
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1978538/
https://www.ncbi.nlm.nih.gov/pubmed/17895999
http://dx.doi.org/10.1371/journal.pone.0000959

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1978538/
https://www.ncbi.nlm.nih.gov/pubmed/17895999
http://dx.doi.org/10.1371/journal.pone.0000959

Ejemplares similares